Lipedema is a disorder that involves the pathologic fat deposition, mostly in the legs. The affected fatty areas often resemble fatty tumors and are quite painful to touch. Lipedema can affect one or more areas of the body in people with the disease.
Lymphedema is a disorder of the lymphatic system and it involves circulation of lymph fluid and is related to the immune system. There is swelling in a leg or an arm when there occurs blockages in the circulation of the lymphatic fluid.